Genova Individual Optimal Nutrition (ION) Test

The Individual Optimal Nutrition (ION) Profile from Genova Diagnostics is a powerful functional test that analyzes over 100 biomarkers across key body systems, including amino acids, vitamins, minerals, fatty acids, organic acids, antioxidants, and more. Using both blood and urine, this test offers a complete picture of how well your body is using nutrients at the cellular and metabolic level.

This is one of the most comprehensive tools available to assess functional deficiencies and underlying imbalances that contribute to symptoms, even when standard bloodwork appears normal.

Why it matters

Micronutrient deficiencies, oxidative stress, and impaired metabolism can all contribute to chronic symptoms such as fatigue, anxiety, poor focus, inflammation, and digestive issues. The ION test helps uncover biochemical imbalances and toxic exposures long before conventional labs detect disease.

By measuring how nutrients are functioning inside your cells, not just their presence in serum, you gain insight into the root contributors to conditions. 

Symptoms it may relate to

• Mood disorders (anxiety, depression)
• Hormonal imbalances and PMS
• Chronic fatigue
• Digestive complaints
• Migraines and joint pain
• Immune dysfunction
• Poor detox or mitochondrial function

What this includes

The ION test evaluates:

• 40 Amino Acids – including essential, branched-chain, and neurotransmitter precursors
• Fatty Acids – omega-3s, omega-6s, omega-9s, and their ratios
• Organic Acids – including mitochondrial, detox, neurotransmitter, and gut markers
• Antioxidants – such as CoQ10, Vitamin E, Glutathione, Cysteine
• Vitamins – A, B-complex, C, D3, K2, Beta-Carotene
• Minerals & Electrolytes – Zinc, Magnesium, Calcium, Potassium, Copper, Selenium
• Toxic Elements & Oxidative Stress Markers – including heavy metals, lipid peroxides, and 8-OHdG
• Metabolic Insights – including glucose-insulin balance, homocysteine, carnitine, and methylation support
  

EFH clinical review and personalized report including:

• Functional interpretation of your micronutrient use
• Targeted dietary and supplement recommendations
• Lifestyle strategies to support nutrient absorption and utilization
• Suggested retest timelines, if needed
  

How it works

• After purchase, you’ll receive the collection kit and detailed instructions.
• The test includes a blood draw and first-morning urine collection.
• Ship the samples to Genova using the included instructions.
• Results are ready in 14 business days.
• EFH will review your results and send a personalized analysis with next steps via email.
  

SAMPLE REPORT 

Important notes

• Not available in NY.
• For accurate results:
  • Reduce fluid intake 24 hours before urine collection
  • Avoid collection during menstruation
  • No need to stop supplements unless advised otherwise
• Kit contains preservatives, follow all shipping and handling instructions
• Most clients and patients who take the Genova ION test benefit from completing the EFH flagship Personalized Health Plan (PHP) alongside testing.

**PURCHASER NOTE: To expedite processing, please include date of birth and gender in ‘Order Notes’ at checkout.